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Center for Nonlinear Studies |
In this talk, we discuss several ways that control theory can help us model the process of self-nonself recognition in the adaptive immune response. We begin by exploring several models of regulatory and helper T-cell growth and communication in the absence of PAMPs or thymic pre-conditioning. In these models, through T-cells response to both antigenic and cytokine stimulation, we demonstrate a potential explanation for self-nonself using differential threat profiles. Following this model development, we use simple ideas from control to understand how these models produce the robust response observed in vivo. Finally, we use advanced computational techniques such as convex optimization and Sum-of-Squares to further refine our models by studying parametric regions of stable response.
Host: Marian Anghel