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Monday, June 30, 2008
3:00 PM - 4:00 PM
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Structural Adaptation of Microvessel Networks in Normal and Tumor Tissues

Timothy Secomb
Department of Physiology and Department of Mathematics, University of Arizona

The circulatory system is a dynamic structure. Blood vessels grow or regress during development and in a variety of normal and disease states, over time scales of hours, days and longer. Under normal conditions, these structural changes ensure that all parts of the tissue are supplied with blood, and that the microvascular network structure is well organized and efficient with regard both to the volume of blood needed and the energy required to drive the flow. Theoretical models have been used to investigate how this is achieved through vessel responses to several stimuli, including wall shear stress, tension in vessel walls, metabolic needs, growth factors, and information transfer along vessel walls, and how perturbations of these processes lead to abnormal structural and functional characteristics in tumor tissues.

Host: Yi Jiang, T-07