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Steven Sanche

Postdoc
T-6/CNLS

Systems Biology and Pharmacology

Steven Sanche

Office: TA-3, Bldg 1690, Room 138
Mail Stop: B258
Phone: (505) 664-0565
Fax:

steven.sanche@gmail.com
home page

Research highlight
     Educational Background/Employment:
    • Ph.D. Pharmaceutical Sciences (2018) Understanding HIV Treatment Efficacy and the Pathogenesis of the Disease, Univ. of Montreal
    • M.Sc. Statistics (2008) Gene Interactions in ADHD, Univ. of Montreal
    • M.Sc. Applied Mathematics (2006) Modeling the Dynamics of Bacterial Resistance, Univ. of Montreal
    • Bidisc. B.Sc. Physics and Mathematics (2004) Biophysics, Univ. of Montreal
    • Employment:
      • 2016-2018 Lecturer - Courses in Pharmacokinetics and Statistics, Univ. of Montreal, Montreal, Canada.
      • 2008-2015 Statistician - Biostatistics and Clinical Epidemiology, St. Mary's Research Centre - St. Mary's Hospital, Montreal, Canada.
      • 2005, 2007, 2015-2018 Assistant Teacher - Courses in Statistics and Real Number Analysis, Univ. of Montreal, Montreal, Canada.
    • Professional Training:
      • 2019-2021 Postdoctoral Research Associate - Los Alamos National Laboratory, New Mexico, US.

    Research Interests:

    • Inter- and Intra-Host Viral Dynamics
    • Biological Signal Detection from Large, Noisy Datasets
    • Physiologically-Based Pharmacokinetics and Systems Pharmacology
    • Informing the Dynamics of Complex Biological Systems using Machine Learning Algorithm

    Selected Recent Publications:

      (Past 3 years only)
    1. Sanche, S., Lin, YT, Chonggang, X., Romero-Severson, E., Hengartner, N., Ke, R. High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2, Emerg. Infect. Dis. 26(7):1470-7 (2020).
    2. Kassem, I., Sanche, S., Li, J., Bonnefois, G., Dube, M.-P., Rouleau, J.-L., Tardif J.-C., White, M., Turgeon, J., Nekka, F. Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure in Clinical and Translational Science, Clinical and Translational Science. https://doi.org/10.1111/cts.12842 (2020).
    3. Rabanel, JM, Adibnia, V., Tehrani, SF, Sanche, S., Hildgen, P., Banquy, X., Ramassamy, C. Nanoparticle heterogeneity: an emerging structural parameter influencing particle fate in biological media?, Nanoscale. 11(2):383-406 (2019).
    4. Sanche, S., Mesplede, T., Sheehan, N., Li, J., Nekka, F. Exploring an alternative explanation for the second phase of viral decay: Infection of short-lived cells in a drug-limited compartment during HAART, PloS one. 13(7):e0198090 (2018).
    5. Landry, S., Chen, CN, Patel, N., Tseng, A., Lalonde, RG, Thibeault, D., Sanche, S., Sheehan, NL Therapeutic drug monitoring in treatment-experienced HIV-infected patients receiving darunavir-based salvage regimens: A case series, Antiviral Research. 152:111-116 (2018).
    6. Sanche, S., Sheehan, N., Mesplede, T., Wainberg, MA, Li, J., Nekka, F. A mathematical model to predict HIV virological failure and elucidate the role of lymph node drug penetration, CPT: pharmacometrics & systems pharmacology. 6(7):469-76 (2017).
    7. Fortin, M., Haggerty, J., Sanche, S., Almirall, J.Self-reported versus health administrative data: implications for assessing chronic illness burden in populations. A cross-sectional study, CMAJ open. 11(6):E729-33 (2017).
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