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Monday, April 15, 2019
3:00 PM - 4:00 PM
CNLS Conference Room (TA-3, Bldg 1690)


Making Movies of Molecules - The Application of X-ray Lasers

Junko Yano
Lawrence Berkeley National Laboratory

Our group is studying the mechanisms of the catalytic reactions in both natural and inorganicsystems. Using various X-ray techniques as tools, we are studying how the catalysts do multielectron reactions, by following the reaction under functional conditions.

We have developed spectroscopy and diffraction techniques necessary to fully utilize thecapability of the X-ray Free Electron Laser facilities (XFELs) for a wide variety of metalloenzymes, and to study their chemistry under functional conditions. One of such methods is simultaneous data collection for X-ray crystallography and X-ray spectroscopy, to look at the overall structural changes of proteins and the chemical changes at metal catalytic sites. In parallel to the detection techniques, we have developed an efficient sample delivery method that involves deposition of droplets on a conveyor belt. This 'Droplet on Tape'(DOT) method, delivers a single drop of the crystal suspension or solution sample onto a tape, which then can be transported to the X ray intersection point with a variable delay in time. In the process, the sample is photochemically or chemically activated at various time delays to capture reaction intermediates with crystallography and spectroscopy.

The presentation will cover our group's recentresults of metalloenzyme research, in particular,for the study of the water oxidation reaction innatural photosynthesis, using X-ray crystallography and X-ray spectroscopy at LCLS(LINAC Coherent Light Source).

IMS is the sponsor of this colloquium.

Host: Michael Wall