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We will look at the problem of explosive dispersal of particles and ask the question what it will take to perform predictive simulations of this complex physics from first principles. Compressible flow resulting from an explosive release of energy is a classic problem. During and after the Second World War, due to interest in better understanding nuclear explosions, this problem attracted some of the best scientists of that time  G.I. Taylor, von Neumann, Hans Bethe, and L.I. Sedov. The presence of particles, as in a hybrid multiphase explosive or dispersal of fragments greatly complicates the problem. The first part of this talk will present an overview of the DoE PSAAPII Center for Compressible Multiphase Turbulence and its accomplishments over the past four years in the areas of compressible multiphase flow, codesign of the exascale code CMTnek, adaptive load balancing for multiphase flow, forensic uncertainty quantification, and exascale performance prediction through behavioral emulation. The second part of the talk will focus on a deepdive of the multiphase flow modeling and simulation. The talk will cover recent results on (a) Development of the Generalized Faxen theorem for modeling of force on a particle subjected to a spatially varying compressible flow (b) application to shockparticle and expansionfanparticle interaction, (c) Extension of the theory to particleparticle interaction effects and the development of the pairwise interaction extended pointparticle (PIEP) model. All these advancements are towards high fidelity EulerLagrange simulations that capture fully resolved physics with orders of magnitude computational saving. Host: Duan Zhong Zhang 