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Tuesday, April 07, 2015
1:00 PM - 2:00 PM
CNLS Conference Room (TA-3, Bldg 1690)


Understanding the mutational processes in human cancer and their relevance for human ageing

Ludmil Alexandrov

Somatic mutations play a key role in the gradual decline of cellular functionality over time and have significant implications for both cancer development and human ageing. These somatic mutations may be the consequence of the intrinsic slight infidelity of the DNA replication machinery, exogenous or endogenous mutagen exposures, enzymatic modification of DNA, or defective DNA repair. Different mutational processes often leave a unique molecular fingerprint on the genome of a cell, termed “mutational signature.” In this talk, I will present the largest to date analysis of genomics data to elucidate the mutational signatures of the molecular processes causing human cancer. Some of these processes are associated with specific phenotypes, while others are relevant for cancer treatment and cancer prevention. Finally, I will briefly discuss mutational processes operating as molecular clocks and their relevance for human ageing. Overall, this talk will reveal the diversity of mutational processes underlying the development of human cancer and the relevance of these processes in human aging.

Host: Kshitij Wagh