Lab Home | Phone | Search
Center for Nonlinear Studies  Center for Nonlinear Studies
 Colloquia Archive 
 Postdoc Seminars Archive 
 Quantum Lunch 
 CMS Colloquia 
 Q-Mat Seminars 
 Q-Mat Seminars Archive 
 Kac Lectures 
 Dist. Quant. Lecture 
 Ulam Scholar 
 Summer Research 
 Past Visitors 
 History of CNLS 
 Maps, Directions 
 CNLS Office 
Thursday, February 19, 2015
11:00 AM - 12:00 PM
CNLS Conference Room (TA-3, Bldg 1690)


Modeling Hepatitis C Viral Kinetic in the Era of Direct Acting Antiviral Agents: Review and Perspectives

Jeremie Guedj
Inserm and Université Paris Diderot

Chronic infection with hepatitis C Virus (HCV) affects 130-200 million people worldwide, including nearly 8 million Europeans. In the last 10 years, active research on understanding mechanisms of HCV replication has resulted in the clinical implementation of direct acting antivirals (DAAs), holding the promise that a virtually universal cure might be achieved in the coming years. Viral kinetic modeling aims to characterize the main mechanisms that govern the virologic response to treatment. These models, most often based on ordinary differential equations, have been initially developed in the field of HIV, providing estimates of key parameters, such as the treatment effectiveness in vivo, the half-life of productively infected cells or the daily rate of viral production.

In this talk I will review the mathematical and statistical developments that have been made in the recent years to apply these models to hepatitis C virus. I will show how these models have been used to guide efforts in clinical drug development. I will conclude on the future challenges on HCV viral kinetic modeling.

Host: Alan Perelson