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Chronic hepatitis C is a liver disease that affects 130 - 150 million people world wide with a significant number that will develop liver cirrhosis or liver cancer (World Health Organization, 2014). Antiviral treatment is available using direct-acting antiviral agents (DAAs). We propose a multiscale age-structured mathematical model that represents both extracellular and intracelllar hepatitis C virus (HCV) dynamics. At a cellular level the HCV interacts with target cells (T) that become infected (I). The length of time a cell has been infected is an important variable within the model. Inside the cell, both positive and negative strands of HCV RNA are represented and the model is fitted to experimental data. This model also allows the simulation of the effectiveness of DAAs in blocking HCV RNA intracellular production and release of new virions. Host: Alan Pererson |