Lab Home | Phone | Search
Center for Nonlinear Studies  Center for Nonlinear Studies
 Home 
 People 
 Current 
 Affiliates 
 Visitors 
 Students 
 Research 
 ICAM-LANL 
 Publications 
 Conferences 
 Workshops 
 Sponsorship 
 Talks 
 Colloquia 
 Colloquia Archive 
 Seminars 
 Postdoc Seminars Archive 
 Quantum Lunch 
 Quantum Lunch Archive 
 CMS Colloquia 
 Q-Mat Seminars 
 Q-Mat Seminars Archive 
 P/T Colloquia 
 Archive 
 Kac Lectures 
 Kac Fellows 
 Dist. Quant. Lecture 
 Ulam Scholar 
 Colloquia 
 
 Jobs 
 Postdocs 
 CNLS Fellowship Application 
 Students 
 Student Program 
 Visitors 
 Description 
 Past Visitors 
 Services 
 General 
 
 History of CNLS 
 
 Maps, Directions 
 CNLS Office 
 T-Division 
 LANL 
 
Thursday, January 22, 2009
10:00 AM - 11:00 AM
CNLS Conference Room (TA-3, Bldg 1690)

Seminar

Modeling HIV/HCV drug treatment and resistance

Liban Rong
LANL, T-6

During the past decade, mathematical models, combined with experimental data, have made significant contributions to our understanding of HIV and other viral infections, such as hepatitis C virus (HCV), hepatitis B virus (HBV), and influenza. However, there are still a lot of questions remaining unanswered. In this talk, I will discuss my recent work at LANL in modeling HIV/HCV infection and drug treatment. I will show how mathematical models help explain low-level HIV persistence, slow decay of the latent reservoir, and emergence of transient episodes of detectable viremia ("HIV blips"), in infected individuals despite apparently potent combination drug therapy (commonly known as the "cocktail therapy") for many years. Using a two-strain model, I will explain why drug resistant virus appears so rapidly in HCV patients treated with a new drug. These results improve our understanding of HIV/HCV dynamics during treatment and may have implications for clinical practice. I will also present a few future directions.

Host: Alan Perelson, T-6