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Thursday, May 29, 2008
2:00 PM - 3:00 PM
CNLS Conference Room (TA-3, Bldg 1690)

Postdoc Seminar

Identification of the structure and dynamics of collective activity in cultured neural networks

Michael Ham
University of North Texas/T-7/CNLS

All higher order central nervous systems exhibit spontaneous neural activity, though the purpose and mechanistic origin of such activity remains poorly understood. We quantitatively analyzed the ignition and spread of collective spontaneous electrophysiological activity in networks of cultured cortical neurons growing on microelectrode arrays. Leader neurons, which form a mono-synaptically connected primary circuit, and initiate a majority of network bursts were found to be a small subset of recorded neurons. Leader/follower firing delay times formed temporally stable positively skewed distributions. Blocking inhibitory synapses usually resulted in shorter delay times with reduced variance. These distributions are characterizations of general aspects of internal network dynamics and provide estimates of pair-wise synaptic distances. Multi-information groups of three or more neurons are identified and characterized by their synergistic or redundant nature. The development of these relationships during maturation shows a shift from synergistic to redundant groups. At the end of the talk, there will a presentation of interesting observations and questions waiting to be addressed.