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Center for Nonlinear Studies |
This talk is part of the Biosystems, Biophysics, and Soft Matter Seminar Series. We explored the relationship between network architecture, single cell behavioral variability, and population dynamics in the chemotaxis system of /Escherichia coli/, one of the simplest sensory systems in biology. We used large-scale agent-based simulations and the fluctuation-dissipation theorem to analyze the stochastic dynamics of the system at the single cell level and its connection to the population behavior. This analysis reveals a network design that exploits the relationship between fluctuations and relaxation time, to simultaneously optimize the searching strategy in the absence of nutrients and the cellular response to gradients of attractant.
Host: Jim Faeder (T-10) and Bill Hlavacek (T-CNLS)