Lab Home | Phone | Search
Center for Nonlinear Studies  Center for Nonlinear Studies
 Home 
 People 
 Current 
 Affiliates 
 Alumni 
 Visitors 
 Students 
 Research 
 ICAM-LANL 
 Quantum 
 Publications 
 Publications 
 2007 
 2006 
 2005 
 2004 
 2003 
 2002 
 2001 
 2000 
 <1999 
 Conferences 
 Workshops 
 Sponsorship 
 Talks 
 Colloquia 
 Colloquia Archive 
 Seminars 
 Postdoc Seminars Archive 
 Quantum Lunch 
 CMS Colloquia 
 Q-Mat Seminars 
 Q-Mat Seminars Archive 
 Archive 
 Kac Lectures 
 Dist. Quant. Lecture 
 Ulam Scholar 
 Colloquia 
 
 Jobs 
 Students 
 Summer Research 
 Student Application 
 Visitors 
 Description 
 Past Visitors 
 Services 
 General 
 PD Travel Request 
 
 History of CNLS 
 
 Maps, Directions 
 CNLS Office 
 T-Division 
 LANL 
 
Jacob Carlson Miner

Postdoctoral Research Associate
CNLS/T-6

Atomistic molecular dynamics, structure prediction

Jacob Carlson Miner

Office: TA-3, Bldg. 1690, Rm. 117
Mail Stop: B258
Phone: 505-667-3216
Fax: N/A

jcminer@lanl.gov
home page

Research highlight
  • LANL News-Release Ribonucleic acid (RNA) tetraloops are common structures that form from short segments of RNA polymers across all domains of life. Despite the commonality of these structures, and their importance to structural stability and catalytic efficacy in living systems, the effects of temperature, pressure, and cosolvents on the energy landscapes of RNA tetraloops are not well characterized. Using advanced computational techniques, and by comparing with studies from experimental groups, we have described complex energy landscapes of a single RNA sequence based on these physical and chemical factors. An intriguing discovery was the emergence of metastable configurations suggested by experiments and never before observed in unbiased computational models. Our work demonstrates the applicability of current RNA modeling methodologies to characterize the equilibrium behaviors of basic biomolecules and has application to other RNA sequences, as well as systems with different biomolecules and varying chemical environments.
 Educational Background/Employment:
  • B.S. (2008) Biology, Secondary Education, Linfield College, McMinnville, OR
  • B.S. (2011) Chemistry, Southern Oregon University, Ashland, OR
  • Ph.D. (2016) Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY
  • Employment:
    • 2008-2009 Conversational English Teacher, Wenzhou University, Wenzhou, Zhejiang Province, PRC
    • 2009-2011 Geneticist, Fish and Wildlife Forensics Laboratory, Department of the Interior, Ashland, OR
    • 2011-2016 Graduate Research Associate, Rensselaer Polytechnic Institute, Troy, NY
    • 2015-2016 Graduate Research Associate, Center for Nonlinear Studies, LANL
    • 2016- Postdoctoral Research Associate, Center for Nonlinear Studies / Theoretical Biology and Biophysics (T-6), LANL
  • Professional Training:
    • 2011-2013 LabVIEW Associate Developer
    • 2014 Short-Term Consultant, Corning Inc., Corning, NY
    • 2016- Rosetta Modeling Software Developer

Research Interests:

  • RNA structural modeling
  • Solution dynamics of RNA/Proteins in the presence of cosolvents
  • Origins of Life

Selected Recent Publications:

  1. Jacob Miner on ResearchGate
  2. Jacob Miner on Google Scholar
  3. Miner, J.C., Garcia, A.E. Concentration-dependent and configuration-dependent interactions of monovalent ions with an RNA tetraloop, J. Chem. Phys. In Review. LA-UR-17-30875
  4. Miner, J.C., Garcia, A.E. Equilibrium denaturation and preferential interactions of an RNA tetraloop with urea, J. Phys. Chem. B. 121(15), 3734-3746 (2017) LA-UR-16-28139
  5. Miner, J.C., Chen, A.A., Garcia, A.E. Free-energy landscape of a hyperstable RNA tetraloop, PNAS, U.S.A. 113(24) 6665-6670 (2016) LA-UR-15-28937
LANL Operated by the Los Alamos National Security, LLC for the National Nuclear Security Administration of the US Department of Energy.
Copyright © 2003 LANS, LLC | Disclaimer/Privacy