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Boian Alexandrov

CNLS Postdoctoral Research Associate
T-4/CNLS

DNA nonlinear dynamics and its relation to biological function

Boian Alexandrov

Office: TA-3, Bldg 1690, Room 125
Mail Stop: B258
Phone: (505) 667-5003
Fax: (505) 665-7652

boian@lanl.gov
home page

 Educational Background/Employment:
  • M.S. Theoretical Physics, Univ. of Sofia
  • Ph.D. Chemical and Nuclear Engineering, Univ. of New Mexico
  • Ph.D. Biophysics and Molecular Biology, Univ. of Sofia, Inst. Molec. Biology
  • Employment:
    • 2004-2006 Research Assistant, Los Alamos National Laboratory, Theoretical Division, T-11 & CNLS.
    • 2006-2008 Research Assistant, Los Alamos National Laboratory, Nuclear Non-Proliferation Division, Science & Technology Group.

Research Interests:

  • DNA Dynamics and biological function
  • Modeling of biological systems
  • Statistical Physics
  • Nonlinear dynamics
  • Radiation detection

Selected Recent Publications:

  1. B. S. Alexandrov, Gelev V, Bishop AR, Usheva A, Rasmussen KO.DNA Breathing Dynamics in the Presence of a Terahertz Field, Phys Lett A. 2010 Feb 22;374(10):1214.PMID: 20174451.
  2. B. S. Alexandrov, Gelev V, Yoo SW, L. Alexandrov, A. R. Bishop, K. O. Rasmussen and A.Usheva DNA Dynamics Play a Role as a Basal Transcription Factor in the Positioning and Regulation of Gene Transcription Initiation, Nucleic Acids Research, Nucleic Acids Res. (2010) Apr 1;38(6):1790-5. Epub 2009 Dec 17.PMID: 20019064.PMID: 20019064.
  3. B. S. Alexandrov, V. Gelev, S. Wook Yoo, A. R. Bishop, K. O. Rasmussen, and A. Usheva, Toward a Detailed Description of the Thermally Induced Dynamics of the Core Promoter, PLoS Comput Biol. 2009;   5(3): e1000313. PMID: 19282962
  4. B. S. Alexandrov, V. Gelev, Y. Monisova, L. B. Alexandrov, A. R. Bishop, K. O. Rasmussen, and A. Usheva, A nonlinear dynamic model of DNA with a sequence-dependent stacking term, Nucleic Acids Res. 2009 Apr;37(7):2405-10. Epub 2009 Mar 5.PMID: 19264801.
  5. B. S. Alexandrov, Rasmussen KO, Bishop AR. Nonlinearity in DNA and its relation to specific functions. J Biol Phys., 2009 Feb;35(1):31-41. Epub 2009 Feb 25. PMID: 19669567.
  6. B. S. Alexandrov, N. K Voulgarakis, K. O. Rasmussen, A. Usheva and A. R Bishop. Pre-melting dynamics of DNA and its relation to specific functions, (2009) J. Phys.: Condens. Matter 21 034107doi: 10.1088/0953-8984/21/3/034107
  7. K.D. Ianakiev, B.S. Alexandrov, P.B. Littlewood, M.C. Browne. Temperature behavior of NaI(Tl) scintillation detectors, Nuclear Instruments and Methods in Physics Research Section A, 607, 2,(2009), 432-438.
  8. Choi, C., Rapti, Z., Gelev, V., B. S. Alexandrov, Park, E., Park, J., Horikoshi, N., Smerzi, A., Rasmussen, K., Bishop, A., Usheva, A. Profiling the Thermodynamic Softness of Adenoviral Promoters, Biophysical Journal.  95,597-608 (2008). PMID: 18390611.
  9. K.D. Ianakiev, Alexandrov, B.S., Boyer, B.D., Hill, T.R., MacArthur, D.W. et all. New generation enrichment monitoring technology for gas centrifuge enrichment plants, IEEE, (2008) p.3055-3059.
  10. B. S. Alexandrov, K. D. Ianakiev, and P. B. Littlewood. Branching Transport Model of Alkali-Halide Scintillators, Nuclear Instruments and Methods in Physics Research A.  586,432-438 (2008).
    PATENT APLICATIONS:
    1. "Method and apparatus for measuring enrichment of UF6 gas in a centrifuge plant" LANL, IDEA 08 -174
    2. "Semiconductor neutron detector" DOE, S-104, 840.
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