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Brian Munsky

CNLS Postdoctoral Research Associate
CNLS

Identification, Reduction and Solution of Natural Stochastic Systems

Brian Munsky

Office: TA-3, Bldg 1690, Room 117
Mail Stop: B258
Phone: 665-6691
Fax: (505) 665-7652

munsky at lanl.gov.
home page

Research highlight
  • See my tutorial slides from the 2008 Q-bio conference: Munsky's Slides Q Bio
  • I was recently awarded the 2007-2008 Best Ph.D Dissertation Award for the Department of Mechanical Engineering at UCSB.
  • I am now a co-organizer for the Center for NonLinear Studies q-bio Seminar Series.
  • Our work on using single cell variability measurements to identify gene regulatory parameters has just been accepted to Molecular Systems Biology.
  • I and David Thorsley recently co-organized the 2nd Workshop on Stochasticity in Biochemical Reaction Networks. Along with Sotiria Lampoudi and Aleksandra Walczak, we will be organizing a third workshop for 2011.
  • I will be traveling to the Bay Area Nov. 30-Dec. 3rd to present research at UC-Berkeley (Nov. 30), UC-San Francisco (Dec. 1), and Stanford (Dec. 3).
 Educational Background/Employment:

Research Interests:

  • I am interested in trying to understand the effects of randomness on dynamical processes in nature, technology and society. I am especially interested in modeling chemical and biological processes as well as epidemilogical processes. At UCSB, I trained in the fields of dynamical systems and control theory. My reason to come to Los Alamos National Lab is to build upon this training and integrate my talents with the diverse skills of physicists and biophysicists at the Center for Non Linear Studies.

Selected Recent Publications:

  1. Bel, G., Munsky, B. and Nemenman, I., Simplicity of Completion Time Distributions for Common Complex Biochemical Processes, Submitted, 2009.[arXiv link]
  2. Munsky, B., Nemenman, I. and Bel, G., Specificity and Completion Time Distributions of Biochemical Processes, Submitted, 2009.[arXiv link]
  3. Munsky, B., Trinh, B., and Khammash, M., Listening to the Noise: Random Fluctuations Reveal Gene Network Parameters, Molecular Systems Biology, 5 , No. 318.[PrePrint][Journal Site]
  4. Munsky, B. and Khammash, M., Transient Analysis of Stochastic Switches and Trajectories with Applications to Gene Regulatory Networks, IET Systems Biology, 2 , No. 2, 323-333 (2008).[.pdf]
  5. Munsky, B. and Khammash, M., Using Noise Transmission Properties to Identify Stochastic Gene Regulatory Networks, Proc. 46th IEEE Conference on Decision and Control, Cancun, Mexico (2008).
  6. Munsky, B. and Khammash, M., Computation of Switch Time Distributions in Stochastic Gene Regulatory Networks, Proc. 2008 American Control Conference, THB10.2, Seattle, WA.[.pdf]
  7. Munsky, B. and Khammash, M., The FSP Approach for the Analysis of Stochastic Noise in Gene Networks, IEEE Transactions on Automatic Control, 53, 201-214 (2008).[.pdf]
  8. Inglesias, P., Khammash, M., Munsky, B., Sontag, E., and Del Vecchio, D., Systems Biology and Control - A Tutorial, Proc. 45th IEEE Conference on Decision and Control, New Orleans, LA (2007).
  9. Munsky, B. and Khammash, M., A Multiple Time Interval Finite State Projection Algorithm for the Solution to the Chemical Master Equation, Journal of Computational Physics, 226, 818-835 (2007).[.pdf]
  10. Munsky, B. and Khammash, M., Analysis of Noise Induced Stochastic Fluctuations in Gene Regulatory Networks , J. SICE, 5, 405-411 (2007).[.pdf]
  11. Peles, S., Munsky, B. and Khammash, M., Reduction and Solution of the Chemical Master Equation Using Time Scale Separation and Finite State Projection, Journal of Chemical Physics, 125, 204104 (2007).[.pdf]
  12. Munsky, B. and Khammash, M., A Reduced Model Solution for the Chemical Master Equation Arising in Stochastic Analyses of Biological Networks, Proc. 45th IEEE Conference on Decision and Control, San Diego, CA (2006).[.pdf]
  13. Munsky, B. and Khammash, M., The Finite State Projection Algorithm for the Solution of the Chemical Master Equation, Journal of Chemical Physics, 124 , 044104 (2006).[.pdf]
  14. Khammash, M. and Munsky, B., Systems Theory Applications in Biology: From Stochastic Chemical Kinetics to Deterministic Model Invalidation, Invited paper-European Control Conference, Kos, Greece (2007).[.pdf]
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