Lab Home | Phone | Search
	Center for Nonlinear Studies
	Home  ▶ People   Current   Affiliates   Alumni   Visitors   Students  ▶ Research   ICAM-LANL  ▶ Publications   2007   2006   2005   2004   2003   2002   2001   2000   <1999  ▶ Conferences   Workshops   Sponsorship  ▶ Talks   Colloquia   Seminars   Quantum Lunch   CMS Colloquia   Archive   Kac Lectures   Dist. Quant. Lecture   Ulam Scholar   Colloquia     Jobs  ▶ Students   Summer Research   Graduate Positions  ▶ Visitors   Description  ▶ Services   General   PD Travel Request     History of CNLS     Maps, Directions   CNLS Office   T-Division   LANL				Friday, June 17, 20113:00 PM - 4:00 PMCNLS Conference Room (TA-3, Bldg 1690) Seminar Stokes Shifts as a Surrogate for Debye Waller Factors, and the Relationship Between Picosecond Dynamics and Alpha Relaxation Marcus T CiceroneBiomaterials Group NIST, Gaitersburg, Maryland For decades, proteins have been stabilized for biotechnology applications by drying them in the presence of sugars. Engineering of the dried sugar (glassy) formulations is currently based on a combination of weakly predictive metrics and long-term stabilization studies. I will show that short-time dynamics in the glass (fast β relaxation), contains a signature that is strongly predictive of long-term protein stability, and will discuss potential reasons for this surprising relationship. I will further show that short-time behavior characteristic of fast β relaxation seen in the intermediate scattering function can be obtained from time-resolved Stokes shifts (TRSS) in glassforming materials. Debye-Waller factor () analogs, extracted from the TRSS data of four glassforming liquids will be compared with neutron scattering to evaluate the robustness of this procedure. I will also comment on putative relationships between α and fast β relaxation. Host: Turab Lookman, T-4, txl@lanl.gov, 665-0419