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William Hlavacek

Executive Committee
CNLS/T-10

Mathmatical Modeling of Complex Biological Systems

William_Hlavacek

Office: TA-3, Bldg. 410, Rm. 136B
Mail Stop: K710
Phone: (505) 665-1355
Fax: (505) 665-3493

wish@lanl.gov
home page

Educational Background/Employment:
  • Ph.D. University of Michigan, 1996
  • Postdoctoral Research Associate, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos NM, 1996-2000
  • Limited-term Technical Staff Member, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, 2000-2004
  • Adjunct Assistant Professor, Department of Biology, University of New Mexico, Albuquerque, NM, 2003-present
  • Technical Staff Member, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, 2004-present
  • Acting Deputy Director, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, 2006-2007

Research Interests:

  • Signal transduction in the immune system
  • Biophysics of ligand-receptor binding
  • Design principles of bacterial gene regulation
  • Metabolomics and metabolic networks in bacteria

Selected Recent Publications:

  1. M.L. Blinov, J.R. Faeder, B. Goldestein and W.S. Hlavacek, BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains., Bioinformatics 20, 3289-3291 (2004).
  2. B. Goldstein, J.R. Faeder and W.S. Hlavacek, Mathematical and computational models of immune-receptor signaling., Nat. Rev. Immunol. 4, 445-456 (2004).
  3. M.E. Wall, W.S. Hlavacek and M.A. Savageau, Design of gene circuts: lessons from bacteria., Nat. Rev. Genet. 5, 34-42 (2004).
  4. W.S. Hlavacek, J.R. Faeder, M.L. Blinov, A.S. Perelson and B. Goldstein, The complexity of complexes in signal transduction., Biotechnol. Bioeng. 84, 783-794 (2003).
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