About
Summary
We are happy to announce the third biennial conference on “Systems Approaches in Immunology and Infectious Diseases,” to be held in Santa Fe, NM on January 10-11, 2014. Our understanding of the immune system is rapidly being transformed by the development of new experimental techniques, including single-cell analysis, in vivo imaging and high-throughput repertoire sequencing. Many of these approaches generate vast amounts of data, and an increasing number of studies seek to apply the methods of mathematical modeling to analyze and integrate these data. The goal of such systems approaches is a global and quantitative understanding of the immune response. However, much of the experimental and theoretical work carried out to-date has focused on questions relating to only one spatiotemporal scale, for example, on understanding signal processing within single cells or population dynamics of T cell responses to viral infections. Further understanding will be advanced by the development of theoretical and experimental techniques and models that bring together phenomena at different levels of complexity to study mechanisms arising at the systems level.
As with the first two international workshops on “Systems Approaches in Immunology,” this meeting will provide a multi-disciplinary forum to discuss the latest developments at the boundary of experimental and computational immunology. It is organized under the premise that understanding of immunology will be advanced by the development of theoretical and experimental techniques and models that bring together phenomena at different levels of complexity. Research themes will be focused on systems-level analysis of immunological processes that span the molecular, cellular, population, and organismal levels, both experimentally and theoretically. Along with sharing new approaches and insights, we hope to generate new collaborative research, and the schedule will be designed to allow plenty of time for interactions beyond the talks and poster sessions.
The meeting will be held under the auspices of the Center for Nonlinear Studies (CNLS) of Los Alamos National Laboratory.
Organizing Committee:
Vitaly Ganusov (U. Tennessee)
Steven Kleinstein (Yale U.)
Alan Perelson (LANL)
Ruy Ribeiro (LANL)
Confirmed Speakers:
Rob de Boer, Utrecht University
Arup Chakraborty, MIT
Damien Chaussabel, Benaroya Research Institute
Garnett Kelsoe, Duke University
Denise Kirschner, University of Michigan
Matthew Krummel, UC San Francisco
Joshua Schiffer, Fred Hutchinson Cancer Research Center
Mark Shlomchik, University of Pittsburgh
John Tsang, NIH
Friday, January 10th
Systems Approaches in Humoral Immunity
Chairs: Steven Kleinstein and Denise Kirschner
9:30-9:40 Introduction and Welcome (Organizing Committee)
9:40-10:10 Mark Shlomchik (Pittsburgh): The ins and outs of germinal centers: memory B cell specification, generation and identity
10:10-10:40 Rob De Boer (Utrecht): How germinal centers evolve broadly neutralizing antibodies
10:40-11:10 Arup Chakraborty (MIT): How to hit HIV where it hurts
11:10-11:30 DISCUSSION AND COFFEE BREAK
11:30-12:00 Garnett Kelsoe (Duke): The origin of natural antibody
12:00-12:30 TBD
12:30-13:00 GENERAL DISCUSSION
13:00-14:30 LUNCH (provided)
Friday, January 10th
Systems Approaches in Cellular Immunity
Chairs: Ruy Ribeiro and Rustom Antia
14:30-14:45 José Borghans (Utrecht): Maintenance of the lymphocyte pool during healthy aging: no signs of peripheral homeostatic compensation
14:50-15:05 Robin Callard (UCL): A mechanistic model of T-cell homeostasis to explain different Tcell reconstitution profiles in HIV-infected children starting ART
15:10-15:25 Julia Drylewicz (Utrecht): Recent thymic emigrants form a considerable population of short-lived naive T cells in mice but not in humans
15:30-15:45 Vitaly Ganusov (Tennessee): Mathematical modeling reveals kinetics of lymphocyte recirculation between major murine organs
15:50-16:30 DISCUSSION AND COFFEE BREAK
16:30-16:45 Benedict Seddon (MRC): Who, where and how much - how cellular heterogeneity influences CTL efficiency
16:50-17:05 Victor Garcia (ETH): The effect of interference on the CD8+ T cell escape rates in HIV
17:10-18:00 GENERAL DISCUSSION
18:00-20:30 Poster Session (Dinner and cash bar)
Saturday, January 11th
Systems Approaches for Understanding Immune Responses
Chairs: Alan Perelson and Rob De Boer
9:00-9:30 Denise Kirschner (Michigan): A systems biology approach to uncover mechanisms governing immunity: tuberculosis as a case study
9:30-10:00 John Tsang (NIH): From whole organisms to individual cells: exploring natural biological variations to study the immune system
10:00-10:30 Matthew Krummel (UCSF): The immune response in 4 dimensions
10:45-11:15 DISCUSSION AND COFFEE BREAK
11:15-11:45 Joshua Schiffer (Fred Hutchinson): Immunologic success and failure against HSV-2 in the human genital tract: the importance of spatial heterogeneity
11:45-12:30 GENERAL DISCUSSION
12:30-14:00 LUNCH (provided)
Saturday, January 11th
Systems Approaches in Signaling etc.
Chairs: Vitaly Ganusov and Robin Callard
14:00-14:15 Lily Chylek (Cornell): Quantified phosphorylation site dynamics reveal mechanisms of T-cell receptor signal initiation
14:20-14:35 Jialiang Wu (Yale): Integrative modeling of interferon stimulated gene transcription
14:40-14:55 Chitra Nayak (Toronto): Computational insights into the role of USP18 in type I interferon refractoriness
15:00-15:15 Rodolphe Thiébaut (INSERM): Integrative analysis of responses to dendritic cell vaccination identifies signatures correlated with control of HIV replication: the DALIA trial
15:20-15:35 Daniel Gadala-Maria (Yale): Genotyping methods for improving detection of immunoglobulin mutations
15:40-16:10 DISCUSSION AND COFFEE BREAK
16:10-16:25 Grant Lythe (Leeds): How many TCR clonotypes does a body maintain?
16:30-16:45 Philip Johnson (Emory): The puzzle of aging TCR repertoires
16:50-17:30 GENERAL DISCUSSION
17:30-17:45 Adjournment and final thoughts (Organizing Committee)
17:45-19:00 Closing Reception (Informal discussions and plan forward)