I am a post-doctoral researcher at the Center for Nonlinear Studies (CNLS) and Theoretical Biology and Biophysics division (T-10), Los Alamos National Laboratory (LANL). My educational background is chemical engineering, but I rather position myself as a computational scientist.

I switched to biology in 2004. My current research activities include:

• development of rule-based algorithms to model biochemical reactions in cell signaling
• stochastic simulations of reaction-diffusion systems using kinetic Monte Carlo, Brownian dynamics and hybrid algorithms
• development of mechanistic models of gradient sensing and cell migration

Computational algorithms I have developed can be widely used to build predictive models of signaling reactions in cells.

Systems studied:

• multivalent ligand-receptor interactions
• aggregation of receptors in the immune response system (high affinity receptors for IgE, T-cell receptors)
• oligomerization of transmembrane protein linker for the activation of T cells (LAT) mediated by adaptor protein Grb2 and nucleatide-exchange factor SOS1
• enzymatic reactions at cell membranes (spatially coupled Ras/PI-3 kinase crosstalk in the PDGF receptor signaling system)
• spatial regulation of PDGF receptor-mediated PI-3 kinase signaling leading to fibroblast invasion during wound healing
• autocrine/paracrine loops in extracellular signaling