Variability dynamics of protein levels in human cells
Alex Sigal, Ron Milo, Ariel Cohen, Tamar Danon, Natalie Perzov, and Uri Alon
- We investigated variability and its temporal dynamics in proteins in human cells. We measured fluctuations in endogenous proteins which were fluorescently labeled by introducing YFP as an additional exon into the coding sequence of one genomic allele. Variability (STD/Mean) ranged between about 0.15 and 0.3 for the proteins studied. Protein level differences between cells were transient: cells higher than average could become lower and vice versa. The timescale for the auto-correlation to decay to half was typically several cell generations. The relatively long auto-correlation time observed in protein levels may account for some of the individuality in cell behavior.
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