Reconstruction of the genome-scale transcriptional regulatory network in E. coli
Bernhardt O. Palsson, B.K Cho, E. Knight (UCSD)
- High-density tiling arrays have been used to perform location analysis for three classes of DNA protein in E. coli and for high resolutions expression profiling. The protein examined are: 1) the RNA polymerase and sigma factors, 2) 12 broad acting transcription factors, and 3) 7 DNA bending protein. This data will be discussed and its representation in an R matrix form discussed. The computation of the functional state of the TRN are illustrated.
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