Modeling the Oscillatory Response of the NF-κB Signaling Pathway

From Q-bio

Diane M. Longo, Alexander Hoffmann, Jeff Hasty, and Lev S.Tsimring

Abstract

The negative feedback architecture of the NF-κB signaling pathway has been shown to produce damped oscillations in NF-κB nuclear-cytoplasmic localization. Beginning with a previously reported large-scale model describing the response of the NF-κB signaling network to external perturbation, we have formulated a simplified nonlinear model consisting of the essential components of the signaling pathway. We have demonstrated that results from the reduced model are in excellent agreement with experiments. Furthermore, we have utilized the reduced model to gain insight into how the NF-κB signaling network may have evolved to produce a robust cellular response in a noisy environment.

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