IL-2 couples T lymphocytes in their activation: from single cell to population

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The interleukin-2 (IL2) mediated feedback pathway integrates the responses of activated T-cells affecting decisions on the population level. We study this circuit on the scale of the single T-cell as well as that of the whole population. On the single cell level we quantitatively measure and model the binding of IL2 to its receptor (IL2r) over short time scales and the effect of this on the production of both IL2 and IL2r. We link this microscopic behavior to global group decisions using in-vitro cultures along with computer simulations.

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