EGF Receptor-Centric Autocrine Circuits in Context-Dependent Cell Signal Processing

From Q-bio

Transactivation of the epidermal growth factor receptor (EGFR) has been proposed to represent a conserved mechanism by which diverse extracellular cues can be integratively processed via a core set of intracellular signaling pathways, across a variety of cell types. In this talk, I will summarize a cohort of related combined quantitative experiment and modeling studies that: [a] place this mechanism within multiple physiological contexts; [b] offer useful methods for its quantitative analysis; and [c] elucidate at least some key aspects of its regulatory topology. The studies described will encompass endeavors undertaken in close collaboration with colleagues including Steve Wiley (Pacific Northwest National Laboratory), Peter Sorger (Harvard Medical School), Stanislav Shvartsman (Princeton University), and Linda Griffith (Massachusetts Institute of Technology).