Dynamics of p53 in non-stressed conditions

From Q-bio

The tumor suppressor protein p53, a key player in DNA damage signaling, is regulated by various feedback loops. The architecture of these feedbacks shapes the dynamic response of the pathway. Ionizing radiation, for instance, induces periodic p53 pulses. Here we focused on investigating p53 dynamics in the absence of exogenous stimuli and detected pulses even in non-stressed conditions. Since the timing of these pulses vary between cells, they are detected only by measuring the dynamics of single cells. We characterized the p53 pulses in non-stressed conditions and examined their sources and function.