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Friday, August 05, 2016
1:00 PM - 2:00 PM
CNLS Conference Room (TA-3, Bldg 1690)

Seminar

Formal diagrammatic methods for modeling large macromolecular complexes

Justin Kinney
Cold Spring Harbor Laboratory

Large protein-DNA complexes play central roles in regulating transcription, DNA replication, and other biological processes. However, there are currently no mathematical methods for efficiently describing such multi-particle complexes in terms of components, interaction energies, and assembly rules. Here we describe mathematical structures that address this need, as well as a diagrammatic formalism that facilitates analytic computations. Our methods can dramatically simplify the analysis of both equilibrium and non-equilibrium stochastic biochemical systems. In particular, the diagrammatic techniques we present greatly facilitate the calculation of partition functions for thermodynamic models of transcriptional regulation.

Host: William Hlavacek