Lab Home | Phone | Search
Center for Nonlinear Studies  Center for Nonlinear Studies
 Home 
 People 
 Current 
 Affiliates 
 Alumni 
 Visitors 
 Students 
 Research 
 ICAM-LANL 
 Publications 
 2007 
 2006 
 2005 
 2004 
 2003 
 2002 
 2001 
 2000 
 <1999 
 Conferences 
 Workshops 
 Sponsorship 
 Talks 
 Colloquia 
 Seminars 
 Quantum Lunch 
 CMS Colloquia 
 Archive 
 Kac Lectures 
 Dist. Quant. Lecture 
 Ulam Scholar 
 Colloquia 
 
 Jobs 
 Students 
 Summer Research 
 Graduate Positions 
 Visitors 
 Description 
 Services 
 General 
 PD Travel Request 
 
 History of CNLS 
 
 Maps, Directions 
 CNLS Office 
 T-Division 
 LANL 
 
Wednesday, December 13, 2006
1:00 PM - 2:00 PM
CNLS Conference Room (TA-3, Bldg 1690)

Seminar

Analysis of networks of oncogenes and tumor-suppressor genes involved in cell cycle checkpoints, apoptosis, and cell survival

Baltazar D. Aguda
Mathematical Biosciences Institute Ohio State University

Oncogenes and tumor-suppressor genes promote and inhibit, respectively, the progression of carcinogenesis. Networks of interactions among these genes in the G1 cell cycle checkpoint (called the Restriction Point), in the regulation of cell death (apoptosis), and in survival signaling pathways will be illustrated. Modularization and qualitative stability analysis of these networks allowed us to reduce their complexity and to identify key control motifs. In the G1 checkpoint, the positive feedback loops in the interactions among Cdc25A, p27Kip1, and CDK2 generate an instability that can explain the switching behavior associated with the Restriction Point. Recent work on the cross-talk between p53 and Akt, which led to a proposed cell survival-death switch, will also be presented.

Host: Yi Jiang T-07